Biotech
Buy The Dip In $MYOK$MYOK has caught our attention after selling off on key data and bouncing off a key support level. Also, key data reported yesterday was positive. Here are the highlights:
A 59-subject Phase 2 clinical trial, MAVERICK-HCM, evaluating MyoKardia's (NASDAQ:MYOK) mavacamten in patients with non-obstructive hypertrophic cardiomyopathy (HCM) (the walls of the ventricles thicken compromising blood flow) met the primary endpoint of safety at week 16.
Meaningful reductions in cardiac stress biomarkers were also noted. The results will be submitted for presentation at a future medical conference.
The company intends to launch additional studies in patients with non-obstructive HCM (will provided a regulatory update in H1 2020) and heart failure with preserved ejection fraction (Phase 2 study should commence in Q2 2020).
On another note, new data from its PIONEER open-label extension study of mavacemten in symptomatic obstructive HCM showed consistent results at week 48 (12 participants) compared to weeks 12, 24 and 36.
Shares closed down 7% after the 5% runup at the end of last week.
MyoKardia, Inc., a clinical stage biopharmaceutical company, discovers, develops, and commercializes targeted therapies for the treatment of serious and neglected rare cardiovascular diseases. Its lead product candidate is mavacamten, an orally administered small molecule, which is in Phase III clinical trial that is designed to reduce left ventricular contractility to alleviate the functional consequences and symptoms of obstructive hypertrophic cardiomyopathy (HCM) and prevent or reverse HCM progression, as well as in Phase II clinical trial for non-obstructive HCM. The company also develops MYK-491, an orally-administered small molecule, which is in Phase IIa clinical trial that is designed to restore normal cardiac muscle contractility in the diseased dilated cardiomyopathy (DCM) heart. Its preclinical programs include MYK-224, a HCM-targeting candidate that is designed to reduce excess cardiac contractility and enhance diastolic function; LUS-1, which is used to counteract a muscle abnormality that results in impaired relaxation of the left ventricle; and ACT-1 targeting genetic DCM due to sarcomeric mutations and impaired calcium regulation. The company has a collaboration with 23andMe, Inc., a consumer genetics and research company. Myokardia, Inc. was founded in 2012 and is headquartered in South San Francisco, California.
As always, trade with caution and use protective stops.
Good luck to all!
$NXTC Still Has Potential$NXTC got hammered on Monday after reporting disappointing data over the weekend. While the stock closed down 52%, it could have been a lot worse and the stock did bounce on the day. This signals that buyers were stepping in.
Here's what happened:
Thinly traded NextCure (NASDAQ:NXTC) closed down 52% on modest volume on the heels of updated results from the first part of its Phase 1/2 clinical trial evaluating NC318, a Siglec-15 (S15)-targeting monoclonal antibody, in patients with solid tumors. The data were presented at the SITC Annual Meeting in Maryland.
Seven dose cohorts (8 mg - 1,600 mg every two weeks) were assessed, predominantly in patients with non-small cell lung cancer (n=13), ovarian cancer (n=7), melanoma (n=7), breast cancer (n=4) and colorectal cancer (n=3). All NSCLC patients failed to respond to PD-1 inhibitor treatment (median of four prior lines of therapy).
Durable responses were observed, including one complete response (ongoing at week 55), one partial response (ongoing at week 28), four NSCLC patients with stable cancer (ongoing at weeks 16 - 40) and 14 participants overall with stable cancer (ongoing at weeks 16 - 42).
On the safety front, 15 patients remain on study implying a discontinuation rate as high as 44% (n=15/34). Most treatment-emergent adverse events (TEAEs) were mild/moderate. There were three serious TEAEs, one case of episcleritis/uveitis and two cases of pneumonitis.
The company has initiated the Phase 2 portion which will evaluate 400 mg administered every two weeks in ~100 patients with NSCLC, ovarian, head and neck and triple-negative breast cancers. The primary endpoints are safety and tolerability. Secondary endpoints include efficacy measures. Preliminary data should be available by late Q4 2020.
NextCure, Inc., a biopharmaceutical company, engages in discovering and developing immunomedicines to treat cancer and other immune-related diseases by restoring normal immune function. Its lead product candidate is NC318, which is in Phase I/II clinical trials for the treatment of advanced or metastatic solid tumors. The company is also developing NC410, is a novel immunomedicine designed to block immune suppression for the treatment of ovarian cancer, non-small cell lung cancer, and renal cancer. Its discovery and research programs include an antibody in preclinical evaluation of other potential novel immunomodulatory molecules that targets a novel member of the B7-family of immunomodulatory proteins; and an antibody in preclinical development targeting an immune modulator that is expressed in inflamed tissue and the tumor microenvironment in various tumor types. NextCure, Inc. has a license agreement with Yale University; and a research and development collaboration with Eli Lilly and Company. The company was founded in 2015 and is based in Beltsville, Maryland.
As always, trade with caution and use protective stops.
Good luck to all!
Nektar should test 21.34 on earnings strength and might fill gapNektar Therapeutics got a big upside surprise on its earnings report for both earnings and revenue. With earnings and revenue trending up, $21-22 is a fair price for the stock given analyst estimates from before the earnings report. There's resistance at 21.34, so we may initially get rejected from that level.
In the near-to-mid-term, however, the earnings beat should lead analysts to revise their forecasts upward. Depending on the size of the revisions, Nektar could attempt a gap fill up to 27.85. (Average analyst price target is over $29.)
NGM, The Little NASH Stock That CouldNGM I remain bullish on NGM's near-term price performance. Seventy-one percent of the outstanding shares are held by insiders and institutions. The largest shareholders being The Column Group L.P, David Goeddel (managing partner at The Column Group), and Peter Svennilson who are lauded in the biopharma industry. Goeddel's last company (Tularik) was sold to Amgen for $1.3 B in 2003. Merck also took a stake worth $450 M before NGM went public which included a 15% equity stake. The key point here is that these are not your everyday stakeholders. They are activists as well as investors. They are in for the long haul and will continue to buy as long as shorts try to bring NGM down as shorts have done to every other NASH stock.
Since October 11th there have been eleven Form-4s. If you look back further you'll see many pages of insider buys since NGM's IPO earlier this year. Today (11/6/19) four more Form-4s came out showing that the insiders above collectively purchased ~$420K worth of stock this week. Buying support like this from the likes of this caliber of scientists and investors sends a strong message to short-sellers. Moreover, it will stoke the interest of investors on the sidelines. The fact that from 1Q19 to 2Q19 the number of hedge funds invested in NGM went from 0 to 10 supports this assumption. There are also multiple intermediate-term catalysts.
In November of 2018 MRK reported positive phase 1b proof of concept data which showed that once-monthly NGM313 had an efficacious effect on insulin-resistant (i.e diabetic) NASH patients. This led to MRK exercising its option to license NGM313 (now MK-3655) from NGM in January 2019. The initiation of the phase 2 study for MK313 could happen at any time and could be catalytic for NGM. Finally, top-line data from NGM's phase 2 NASH study is expected in the first quarter of 2020. In my opinion, this data readout has the potential to propel NGM like Constellation Pharmaceuticals (CNST) which closed up 90% today (11/6/19) after announcing promising phase 2 data. To this point, CNST is another stock that The Column Group has a significant stake in (6.2 million shares, 18% ownership). Whereas in NGM they own 16.5 M shares (25% ownership stake). I don't know about you but I concentrate my capital on my top picks.
A final aspect of my thesis is that shorts have not covered since there latest attacks. Based on data available on iborrow, the number of shares available to borrow went down to 20K this week from 100K last week. Assuming I am correct, and shorts can not successfully bring NGM down, the combination of shorts covering and longs buying will fuel the next leg up. As I discussed above the float is locked up and sits at 22 M. Under these conditions, we could see a strong move up.
SGMO will history repeat itself?This company has been getting a lot of exposure in the buy-o-tech sektor. I have no idea what i'm doing but this looks like a winna 2 me.
Photocure $PHO.OL stock could break out after Q3 presentationPhotocure OSL:PHO presented Q3 numbers with top line numbers just a hint weaker than consensus, but with the strongest quarterly growth rate in deployed cystoscopes ever noted.
The stock is currently trading above earlier support, and a move through NOK 60 could trigger a strong BUY signal.
Q3 Report:
photocure.com
Q3 webcast in english with CEO Daniel Schneider of Photocure:
webtv.hegnar.no
NGM outcherehere we go again fellas. past earning have led to quick gains the following week. I might sell in a week idk yet. L8R
Potential Reversal Marker TherapeuticsMRKR
Entered MRKR at $4.01 on Friday (11/1/19) and am monitoring for a sustained trend reversal. Watching for SP to bounce off $4.10, or if that does not hold, $4.01. If it does not reverse here I think it'll consolidate between $3.83 and $4.32. A reversal would coincide with a run-up into Q3 earnings which should be sometime this month and phase 2 data in Ovarian Cancer expected this quarter. Closing over $4.32 would be a good confirmation of a trend reversal. RSI and CCI on the daily support the stock is building momentum IMO.
NGM Post Data ChannelI exited NGM for a 26% gain yesterday and re-entered today at $12.80. The stock appears to found a new channel following the release of interim phase 2 NASH data. This trade involves chart patterns and fundamentals. NGM is backed by Column Group L.P and Merck (MRK). Their data was positive. The float is very low and locked up by the above NGM shareholders. Should bounce to ~$14.0. Could break out to the $16.0 range.
NUVA BUYBUY signal at 65.73$.
Timeframe - 1 week.
Nuvasive, Inc. is a medical device company. The Company focuses on developing minimally-disruptive surgical products and procedurally-integrated solutions for the spine surgery. Its product portfolio focuses on applications for spine fusion surgery, including biologics used to aid in the spinal fusion process.
If you want to see more history of this strategy, I able to show you if you request me.
It's one of two signal algo for NUVA.
ATTENTION this strategy may has downtrend about 10-15%, so you can split your buy order, that you have not big downtrend.
__________________________________________________________________________
You can use the signals independently or like indicator of trends together with other indicators in your trading strategy.
Know that the success of your strategy that based on those signals depends from your money management and the additional conditions that you make in these strategies.
You use these signals inside your strategies at your own risk.
The chart shows the last trades on the product + the last signal.
I have several strategies for different products, and I want to show you proof of it works on history, and you will be able to see it, when returns to that profile.
Therefore, subscribe and watch for that profile.
The signals rare but useful.
Harmonic ButterflyMRKR showing signs of life after testing a key Fibonacci level of support.
Chart:
Double bottom
CCI moved positive (inferring a nice loading zone)
MS Signal is showing "Over-Sold" conditions
Key *Support needs to hold $3.80
Key *Resistance at $4.53 then $5.29 (highlighted in green shaded area)
Disclosure: I do not own MRKR. I may buy/ sell within the next 72 hours. This is not a recommendation to buy or sell. Please do your homework before investing.
Can TTNP Actually Gap Fill Or Is It Forever Going To Trade Here?TTNP has been catching attention on volume scans this month. Ever since gapping down on October 16, the daily action is noticeably greater than before. But is this a good or bad sign for the penny stock? Currently trading around $0.20. OS is around 17 million so it's not the biggest out there but not the smallest either.
Titan Pharmaceuticals is a company that develops treatments for chronic diseases using its ProNeura platform. Titan announced a $9 million public offering a week ago. While the company’s stock took a price hit due to the per-share pricing of the offering it is okay.It is okay because ever since the company did this, a surge of volume has entered the stock. In addition to this, analysts are taking notice of the company too. Maxim Group upgraded TTNP stock from “HOLD” to “BUY” this week and gave a $1 price target.
ABOUT TTNP
Titan Pharmaceuticals Inc is a specialty pharmaceutical company. It is engaged in the development of pharmaceutical products. Its product pipeline consists of Probuphine for Opioid addiction, Ropinirole for Parkinson's disease, Triiodothyronine (T3) for hypothyroidism. It generates revenue principally from collaborative research and development arrangements, technology licenses, and government grants.
QUOTE SOURCE: 4 Penny Stocks Catching Biotech Investors By Surprise
$SGEN Shorterm BearishHello Traders!
It looks like $SGEN has made a local top and will be headed for consolidation. Not to worry, I believe continued upside potential is favored. My plan includes stacking buy orders at $90-$75 with stops at $70. Do your own DD, and good luck!
Yo boy,
Pic
Abbvie brakes 200SMA ABBV is currently breaking the 200sma, ending a 14 month downtrend.
On the next days I will be tracking the next tools:
OBV should trend higher to confirm this new uptrend. It still has not done that.
3 candlestick closes above the 200SMA would also be a confirmation signal.
